Rare Neurology News
Advertisement
Disease Profile
Systemic candidiasis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
#N/A
Age of onset
#N/A
ICD-10
#N/A
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Systemic candida infections; Invasive Candidiasis
Summary
Systemic candidiasis includes a spectrum of yeast infections caused by different species (types) of Candida.[1] It is a serious infection that can affect the blood, heart, brain, eyes, bones, or other parts of the body.[2] Although there are over 200 species of Candida, five different species of Candida cause 90% of systemic candidiasis.[1][2][3] The most common form of this invasive yeast infection is when Candida enters the bloodstream (candidemia). Signs of candidemia include fever and chills that do not improve with
Symptoms
Systemic candidiasis may also affect other parts of the body such as the
Cause
People who may have an increased risk for systemic candidiasis include:[1][2][3]
- People who have a weakened
immune system (for example, people who have had an organ transplant, have HIV/AIDS, or are oncancer chemotherapy ) - Intensive care unit (ICU) patients
- People who have had surgery, especially gastrointestinal surgery
- People who have a central venous catheter
- Very low-birth-weight infants
- People who have taken broad-spectrum
antibiotics - People who have a very low neutrophil (a type of
white blood cell ) count (neutropenia) - People who have kidney failure or are on hemodialysis
- People who have diabetes
Diagnosis
However, in 40-50% of cases when systemic candidiasis affects another part of the body, the blood culture may be negative.[1][2] In these cases, further testing will depend on which
Treatment
Antifungal medications may be given to certain high risk people in order to prevent the development of systemic candidiasis, however more studies are needed before it is clear if this practice is helpful.[2][6]
For more information about the treatment of systemic candidiasis, please see the Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- You can obtain information on this topic from the Centers for Disease Control and Prevention (CDC). The CDC is recognized as the lead federal agency for developing and applying disease prevention and control, environmental health, and health promotion and education activities designed to improve the health of the people of the United States.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manual provides information on this condition for patients and caregivers.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for health care professionals provides information on Systemic candidiasis.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Systemic candidiasis. Click on the link to view a sample search on this topic.
References
- Antinori S, Milazzo L, Sollima S, Galli M, and Corbellino M. Candidemia and invasive candidiasis in adults: A narrative review. Eur J Intern Med. October 2016; 34:21-28. https://www.ncbi.nlm.nih.gov/pubmed/27394927.
- Invasive Candidiasis. Centers for Disease Control and Prevention. June 12 2015; https://www.cdc.gov/fungal/diseases/candidiasis/invasive/.
- Hidalgo JA. Candidiasis. Medscape Reference. November 4 2016; https://emedicine.medscape.com/article/213853-overview.
- Vyas JA. Endocarditis. Medline Plus. December 7 2014; https://medlineplus.gov/ency/article/001098.htm.
- Pfaller MA, Wolk DM,and Lowery TJ. T2MR and T2Candida: novel technology for the rapid diagnosis of candidemia and invasive candidiasis. Future Microbiol. January 2016; 11(1):103-17. https://www.ncbi.nlm.nih.gov/pubmed/26371384.
- Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, and Sobel JD. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. February 2016; 62(4):e1-50. https://cid.oxfordjournals.org/content/62/4/e1.
Rare Neurology News