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Disease Profile
Syringomyelia
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-9 / 100 000
Age of onset
All ages
ICD-10
G95.0 Q06.4
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Categories
Congenital and Genetic Diseases
Summary
Syringomyelia is a condition in which a cyst, called a syrinx, forms within the spinal cord. This cyst expands and elongates over time, destroying the center of the spinal cord which can result in pain, weakness, stiffness in the back, shoulders, arms, or legs, headaches, and insensitivity to temperature (especially in the hands). Symptoms vary from person to person. Syringomyelia is often related to a
Treatment often involves surgery and avoiding activities that involve straining. Drainage of the cysts using a
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
Percent of people who have these symptoms is not available through HPO | ||
Abnormality of the foramen magnum | 0002699 | |
Areflexia of upper limbs | 0012046 | |
Arnold-Chiari type I malformation | 0007099 | |
0000006 | ||
Babinski sign | 0003487 | |
Difficulty articulating speech
|
0001260 | |
Enlarged sagittal diameter of the cervical canal | 0005878 | |
Gait |
Inability to coordinate movements when walking
|
0002066 |
Horner |
0002277 | |
Limb muscle weakness |
Limb weakness
|
0003690 |
Lower limb hyperreflexia |
Overactive lower leg reflex
|
0002395 |
Lower limb |
0002061 | |
Neck pain | 0030833 | |
Involuntary, rapid, rhythmic eye movements
|
0000639 | |
Paresthesia |
Pins and needles feeling
Tingling
[ more ] |
0003401 |
0002650 | ||
Syringomyelia |
Fluid-filled cyst in spinal cord
|
0003396 |
Unsteady gait |
Unsteady walk
|
0002317 |
Urinary incontinence |
Loss of bladder control
|
0000020 |
Diagnosis
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
American Syringomyelia & Chiari Alliance Project (ASAP)
PO Box 1586
Longview, TX 75606-1586
Toll-free: 1-800-272-7282
Telephone: +1-903-236-7079
Fax: +1-903-757-7456
E-mail: [email protected]
Website: https://asap.org/ -
Bobby Jones Chiari & Syringomyelia Foundation (Bobby Jones CSF)
c/o Dorothy Poppe
29 Crest Loop
Staten Island, NY 10312
Telephone: +1-718-966-2593
Fax: +1-718-966-2593 (please call first)
E-mail: [email protected]
Website: https://bobbyjonescsf.org/ -
Worldwide Syringomyelia & Chiari Task Force Inc.
PO Box 491975
Lawrenceville, GA 30049
Telephone: +1-914-510-CURE (2873)
E-mail: [email protected]
Website: https://www.wstfcure.org
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The Chiari & Syringomyelia Foundation, Inc. offers information on Syringomyelia
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Syringomyelia. Click on the link to view a sample search on this topic.
References
- NINDS Syringomyelia Information Page. National Institute of Neurological Disorders and Stroke (NINDS). April 5, 2016; https://www.ninds.nih.gov/Disorders/All-Disorders/Syringomyelia-Information-Page.
- Hassan Ahmad Hassan Al-Shatoury. Syringomyelia. Medscape. Jul 08, 2016; https://emedicine.medscape.com/article/1151685-overview.
- About Syringomyelia. Chiari & Syringomyelia Foundation. 4/2016; https://csfinfo.org/files/2914/6170/1074/About_SM-web.pdf.
- Syringomyelia Fact Sheet. National Institute of Neurological Disorders and Stroke (NINDS). April 5, 2016; https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Syringomyelia-Fact-Sheet.
- Al-Shatoury HAH, Galhorn AA, Wagner FC. Syringomyelia: Differential Diagnosis & Workup. Medscape Reference. Jul 08, 2016; https://emedicine.medscape.com/article/1151685-diagnosis.
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