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Disease Profile
Parsonage Turner syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-5 / 10 000
Age of onset
Adult
ICD-10
G54.5
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Acute brachial neuritis; Acute brachial neuritis syndrome; Acute brachial radiculitis syndrome;
Categories
Nervous System Diseases
Summary
Parsonage Turner
PTS is one of two forms of neuralgic amyotrophy. The other form is hereditary and is caused by
Symptoms
In some cases, nerves and muscles outside of the shoulder and upper arm region are affected, such as the lumbosacral plexus (causing symptoms in the legs) or phrenic nerve (affecting the diaphragm).[3]
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Arthralgia |
Joint pain
|
0002829 |
EMG abnormality | 0003457 | |
Muscle weakness |
Muscular weakness
|
0001324 |
Polyneuropathy |
Peripheral nerve disease
|
0001271 |
30%-79% of people have these symptoms | ||
Paresthesia |
Pins and needles feeling
Tingling
[ more ] |
0003401 |
Scapular winging |
Winged shoulder blade
|
0003691 |
Sprengel anomaly |
High shoulder blade
|
0000912 |
5%-29% of people have these symptoms | ||
Acrocyanosis |
Persistent blue color of hands, feet, or parts of face
|
0001063 |
Cleft roof of mouth
|
0000175 | |
Narrow mouth |
Small mouth
|
0000160 |
Neurological speech impairment |
Speech disorder
Speech impairment
Speech impediment
[ more ] |
0002167 |
Respiratory insufficiency |
Respiratory impairment
|
0002093 |
Round face |
Circular face
Round facial appearance
Round facial shape
[ more ] |
0000311 |
Decreased body height
Small stature
[ more ] |
0004322 | |
Sleep disturbance |
Difficulty sleeping
Trouble sleeping
[ more ] |
0002360 |
Cause
- Infections (both viral and bacterial)
- Surgery
- Vaccinations
- Childbirth
- Certain medical procedures, such as a spinal tap or
imaging studies that require administration of radiologic dye - Strenuous exercise
- Certain medical conditions, including
connective tissue disorders and autoimmune disorders - Injury
Some researchers believe that Parsonage Turner syndrome is a multifactorial condition, which means that it is caused by an interaction between environmental and genetic factors. In this case, a person may have a genetic susceptibility to PTS due to one or more
Diagnosis
Treatment
Pain medications may be prescribed depending on the severity of the nerve pain. After the acute phase, different medications known as co-analgesics may be administered. These include gabapentin, carbamazepine, and amitriptyline. These drugs specifically treat nerve pain. Other techniques for pain management include application of heat or cold, and transcutaneous electrical nerve stimulation, a method of pain relief in which a special device transmits low-voltage electrical impulses through electrodes on the skin to an area of the body that is in pain.[1][2]
PTS symptoms may get better with time. However, it is not uncommon for some symptoms to persist. These symptoms are best treated by rehabilitation centers.[6] Surgeries such as nerve grafting or tendon transfer to restore movement and function to the shoulder muscles and joint may be considered if other treatment options are not effective.[1][2]
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
American Chronic Pain Association (ACPA)
P.O. Box 850
Rocklin, CA 95677-0850
Toll-free: 800-533-3231
Telephone: 916-632-0922
Fax: 916-652-8190
E-mail: [email protected]
Website: https://theacpa.org/ -
The Foundation for Peripheral Neuropathy
485 Half Day Road
Suite 350
Buffalo Grove, IL 60089
Telephone: +1-877-883-9942
Fax: +1-847-883-9960
E-mail: https://www.foundationforpn.org/contact-us/
Website: https://www.foundationforpn.org
Organizations Providing General Support
-
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
Toll-free: 800-598-4668
Telephone: 586-776-3900
Fax: 586-776-3903
E-mail: [email protected]
Website: https://www.aarda.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Parsonage Turner syndrome. Click on the link to view a sample search on this topic.
References
- Parsonage Turner syndrome. NORD. Updated 2020; https://rarediseases.org/rare-diseases/parsonage-turner-syndrome/.
- Nigel L Ashworth. Brachial Neuritis. Medscape Reference. January 18, 2017; https://emedicine.medscape.com/article/315811-overview.
- Neuralgic amyotrophy. Orphanet. January 2013; https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=2901.
- Joaquim AF, Makhni MC, Riew KD. Post-operative nerve injuries after cervical spine surgery. Int Orthop. Apr 2019; 43(4):791-795. https://pubmed.ncbi.nlm.nih.gov/30498911/.
- Gstoettner C, Mayer JA, Rassam S, Hruby LA, Salminger S, Sturma A, Aman M, Harhaus L, Platzgummer H, Aszmann OC. Neuralgic amyotrophy a paradigm shift in diagnosis and treatment. J Neurol Neurosurg Psychiatry. Aug 2020; 91(8):879-888. https://pubmed.ncbi.nlm.nih.gov/32487526/.
- Van Eijk JJ, Groothuis JT, Van Alfen N. Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment. Muscle Nerve. Mar 2016; 53(3):337-50. https://pubmed.ncbi.nlm.nih.gov/26662794/.
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