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Disease Profile
Glioma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-5 / 10 000
Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Categories
Rare Cancers
Summary
Glioma refers to a type of brain
- Astocytoma tumors that develop from star-shaped glial cells called astrocytes
- Ependymomas tumors that arise from ependymal cells that line the ventricles of the brain and the center of the spinal cord
- Oligodendrogliomas tumors that affect the oligodendrocytes
The symptoms of glioma vary by type but may include headaches; nausea and vomiting; confusion; personality changes; trouble with balance; vision problems; speech difficulties; and/or
Diagnosis
Making a diagnosis for a genetic or rare disease can often be challenging. Healthcare professionals typically look at a person’s medical history, symptoms, physical exam, and laboratory test results in order to make a diagnosis. The following resources provide information relating to diagnosis and testing for this condition. If you have questions about getting a diagnosis, you should contact a healthcare professional.
Testing Resources
- Orphanet lists international laboratories offering diagnostic testing for this condition.
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- 5-aminolevulinic acid(Brand name: Gleolan) Manufactured by NX Development Corporation
FDA-approved indication: Opticalimaging agent indicated in patients with glioma (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for the visualization of malignanttissue during surgery.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Polifeprosan 20 with carmustine(Brand name: Gliadel®) Manufactured by Eisai
FDA-approved indication: Expanding the indication to include patients with malignant glioma undergoing primary surgical resection.
National Library of Medicine Drug Information Portal - Temozolomide(Brand name: Temodar®) Manufactured by Schering-Plough
FDA-approved indication: Treatment of adult patients with newly diagnosed glioblastoma multiforme concomitatly with radiotherapy and then as maintenance treatment
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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American Brain Tumor Association
8550 W. Bryn Mawr Ave, Ste 550
Chicago, IL 60631
Toll-free: 1-800-886-2282
Telephone: +1-773-577-8750
Fax: +1-773-577-8738
E-mail: [email protected]
Website: https://www.abta.org/ -
Brain Foundation
P O Box 579
Crows Nest, NSW
1585 Suite 21
Regent House 37-43
Alexander Street Crows Nest, NSW 2065
Australia
Telephone: 61 2 9437 5967
Fax: 61 2 9437 5978
E-mail: https://brainfoundation.org.au/contact
Website: https://www.brainfoundation.org.au/ -
International Brain Tumour Alliance
10 Carrodus Street,
Fraser, ACT, 2615
Australia
E-mail: [email protected]
Website: https://www.theibta.org/ -
National Brain Tumor Society
55 Chapel St., Suite 200
Newton, MA 02458
Telephone: +1-617-924-9997
Fax: +1-617-924 -9998
E-mail: https://braintumor.org/our-mission/contact-us/
Website: https://braintumor.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The American Brain Tumor Association has an information page on Glioma. Click on the link to view this information page.
- The Mayo Clinic Web site provides further information on Glioma.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- The Merck Manual for health care professionals provides information on Glioma.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Glioma. Click on the link to view a sample search on this topic.
References
- Glioma. Mayo Clinic. April 2015; https://www.mayoclinic.org/diseases-conditions/glioma/home/ovc-20129412.
- Lawrence D Recht, MD. Diagnosis and classification of low-grade gliomas. UpToDate. June 2014; Accessed 7/15/2015.
- Tracy Batchelor, MD, MPH; William T Curry, Jr, MD. Clinical manifestations and initial surgical approach to patients with high-grade gliomas. UpToDate. July 2015; Accessed 7/15/2015.