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Disease Profile
Digestive System Melanoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Melanoma of the gastrointestinal tract; Melanoma of the GI tract; Malignant melanoma of the gastrointestinal tract;
Categories
Rare Cancers
Summary
Digestive system
Cause
- The
cancer originated from a undetectable primarytumor that spontaneously (naturally) regressed on its own - The cancer originated from a primary tumor that is so small it can not be detected using standard clinical and laboratory investigations
- Early melanocyte
cells (not usually found in the digestive system) lost their way during the development of the baby in the womb, and that these misplaced cells later became cancerous
Diagnosis
I. The identification of a single solitary melanoma in the mucosa of the digestive system
II. The presence of other melanoma in the surrounding areas of the digestive system
III. The absence of cutaneous melanoma or other atypical skin tumors in the melanocytes
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Aldesleukin(Brand name: Proleukin) Manufactured by Chiron Corporation
FDA-approved indication: Treatment of adults with metastatic melanoma.
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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Melanoma Research Alliance (MRA)
730 15th Street, NW
Washington, DC 20005
Telephone: +1-202-336-8935
E-mail: [email protected]
Website: https://www.curemelanoma.org/
Social Networking Websites
- Visit the Rare Cancer & Tumors group on Facebook.
Organizations Providing General Support
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American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org -
Cancer Hope Network
2 North Road, Suite A
Chester, NJ 07930
Toll-free: 1-877-467-3638 (1-877-HOPENET)
Telephone: +1-908-879-4039
Fax: +1-908-879-6518
E-mail: [email protected]/
Website: https://www.cancerhopenetwork.org/ -
CancerCare
275 Seventh Ave, Floor 22
New York, NY 10001
Toll-free: 800-813-HOPE
Fax: 212-712-8495
E-mail: [email protected]
Website: https://www.cancercare.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- PubMed is a searchable database of medical literature and lists journal articles that discuss Digestive System Melanoma. Click on the link to view a sample search on this topic.
References
- Letovanec I, Vionnet M, Bouzourene H. . Primary appendiceal melanoma: Fiction or reality?. Human Pathol. 2004 May;
- Andreas V. Hadjinicolaou,corresponding author1 Christopher Hadjittofi, Panagiotis G. Athanasopoulos, Rahul Shah,Aftab A. Ala. Primary small bowel melanomas: fact or myth?. Ann Transl Med. Mar 2016; 4(6):113. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828744/.
- Atmatzidis KS et al.,. Primary malignant melanoma of the small intestine: Report of a case. Surg Today. 2002;
- Lagoudianakis EE et al.,. Primary gastric melanoma: A case report. World J. Gastroenterology. 2006 July 21;
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