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Disease Profile
Adrenocortical carcinoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-9 / 1 000 000
Age of onset
Childhood
ICD-10
C74.0
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
ACC
Categories
Blood Diseases; Endocrine Diseases; Female Reproductive Diseases;
Summary
Adrenocortical carcinoma is a rare
Adrenocortical carcinoma may develop by chance alone, but at least 50% of the cancers are thought to be hereditary. There are a number of
An adrenocortical carcinoma is diagnosed based on urine tests for abnormal levels of cortisol, the hormone released by the adrenal glands. Blood tests can also be conducted to measure levels of potassium and sodium in the blood. A
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
100% of people have these symptoms | ||
Adrenocortical carcinoma | 0006744 | |
30%-79% of people have these symptoms | ||
Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
Abnormal serum dehydroepiandrosterone level | 0500022 | |
Abnormality of reproductive system physiology |
Genital functional abnormality
|
0000080 |
Adrenocorticotropic |
0011748 | |
Anxiety |
Excessive, persistent worry and fear
|
0000739 |
0000819 | ||
Elevated serum 11-deoxycortisol | 0025436 | |
Hyperaldosteronism |
Elevated plasma aldosterone
Increased aldosterone
Increased aldosterone production
[ more ] |
0000859 |
Hyperhidrosis |
Excessive sweating
Increased sweating
Profuse sweating
Sweating
Sweating profusely
Sweating, increased
[ more ] |
0000975 |
0000822 | ||
Hypertrichosis | 0000998 | |
Hypokalemia |
Low blood potassium levels
|
0002900 |
Increased body weight | 0004324 | |
Increased serum androstenedione | 0025380 | |
Increased serum estradiol | 0025134 | |
Increased urinary cortisol level |
High urine cortisol level
|
0012030 |
Irritability |
Irritable
|
0000737 |
Lung adenocarcinoma | 0030078 | |
Muscle weakness |
Muscular weakness
|
0001324 |
Palpitations |
Missed heart beat
Skipped heart beat
[ more ] |
0001962 |
Panic attack | 0025269 | |
Paradoxical increased cortisol secretion on dexamethasone suppression test | 0003466 | |
Striae distensae |
Stretch marks
|
0001065 |
Weight loss | 0001824 | |
5%-29% of people have these symptoms | ||
Abnormality of urine homeostasis |
Pee issues
Urine issues
[ more ] |
0003110 |
Percent of people who have these symptoms is not available through HPO | ||
0000006 |
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
|
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Differential diagnosis should include phaeochromocytoma and neuroblastoma (see these terms).
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
Kidney Cancer Association
1234 Sherman Avenue
Suite 203
Evanston, IL 60202-1375
Toll-free: 1-800-850-9132
Telephone: 312-436-1455
Fax: +1-503-215-7921 (Nurse Hotline)
E-mail: [email protected]
Website: https://www.kidneycancer.org/ -
Primary Aldosteronism Foundation
3533 E Ahwatukee CT
Phoenix, AZ 85044
Telephone: (602) 726-0665
E-mail: [email protected]
Website: https://www.primaryaldosteronism.org/ -
Rare Cancer Alliance
1649 North Pacana Way
Green Valley, AZ 85614
Telephone: 520-625-5495
Website: https://www.rare-cancer.org -
The National Coalition for Cancer Survivorship
1010 Wayne Avenue
Suite 770
Silver Spring, MD 20910
Toll-free: 888-650-9127
Telephone: 301-650-9127
Fax: 301-565-9670
E-mail: [email protected]
Website: https://www.canceradvocacy.org
Organizations Providing General Support
-
American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org -
Cancer Hope Network
2 North Road, Suite A
Chester, NJ 07930
Toll-free: 1-877-467-3638 (1-877-HOPENET)
Telephone: +1-908-879-4039
Fax: +1-908-879-6518
E-mail: [email protected]/
Website: https://www.cancerhopenetwork.org/ -
CancerCare
275 Seventh Ave, Floor 22
New York, NY 10001
Toll-free: 800-813-HOPE
Fax: 212-712-8495
E-mail: [email protected]
Website: https://www.cancercare.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
Adrenal Carcinoma
Adrenal Carcinoma Imaging - The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Adrenocortical carcinoma. Click on the link to view a sample search on this topic.
References
- Dr. Bernadette Brennan. Adrenocortical carcinoma. Orphanet; June 2007; https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=1501.
- Victor A. McKusick and George E. Tiller. Adrenocortical Carcinoma, Hereditary; ADCC. Online Mendelian Inheritance in Man; November 21, 2011; https://www.omim.org/entry/202300.
- Adrenocortical Carcinoma Treatment. National Cancer Institute; May 27, 2016; https://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq.