5 Facts you should know about

Wolfram syndrome

Diabetes mellitus is typically the first manifestation, usually diagnosed around age 6

The observation of optic nerve atrophy after the diagnosis of diabetes mellitus is often a clue to the diagnosis

Urinary tract problems affect 60 to 90 % of patients

Most patients die prematurely with severe neurological disabilities

The median age at death is approximately 30 years, usually from respiratory failure as a result of brain stem atrophy

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