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5 Facts every neurologist should know about
Diagnosing Lennox-Gastaut syndrome
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Lennox-Gastaut syndrome (LGS) typically manifests in childhood, with the majority of cases emerging between the ages of 3 and 5 years
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LGS is characterized by a triad of multiple seizure types, cognitive impairment, and an abnormal electroencephalogram (EEG) pattern
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Seizure types include atonic seizures, tonic seizures, and atypical absence seizures. These seizures often occur daily
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The EEG background in LGS often exhibits a slow and disorganized pattern, characterized by slow spike-and-wave complexes. Recognition of these specific EEG abnormalities is vital for the accurate diagnosis of LGS
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Another characteristic of LGS is the failure to respond to multiple antiseizure medications (ASMs). Typically, patients with LGS have tried and failed with at least 2 or more ASMs before being diagnosed with the syndrome