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Five “relatively unknown” facts about

Diagnosing Lennox-Gastaut Syndrome in Adults

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1

In adulthood, one or more of the classic symptoms of Lennox-Gastaut syndrome (LGS) may no longer be evident

2

Different EEG activities may be present in adult patients with LGS - this may result in missed diagnoses in these patients and subsequent challenges for the adequate treatment of their seizures

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3

The types of seizures experienced by individuals with LGS can change over time. This means that the seizure presentation may vary and become more complex as the person ages

4

Diagnosing LGS in adolescents and adults is particularly problematic as details of medical history may be lost during transfer from pediatric to adult care

5

The refractory epilepsy screening tool for Lennox–Gastaut syndrome (REST-LGS) is a promising instrument for aiding clinicians in differentiating between LGS and other refractory epilepsies

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Learn more about diagnosing LGS
The REST-LGS is a screening tool created by a group of experts in the field of epilepsy to improve the identification and treatment of patients living with Lennox-Gastaut syndrome.

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References:
Wheless, J. W. (2008). Chapter 27 Lennox-Gastaut Syndrome: A Review. In J. W. Wheless (Ed.), Advanced Therapy in Epilepsy (pp. 293–309). PMPH-USA. Arzimanoglou, A., French, J., Blume, W. T., & Cross, J. H. (2009). Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. The Lancet Neurology, 8(1), 82–93. https://doi.org/10.1016/S1474-4422(08)70256-8 Cross, J. H., Auvin, S., Falip, M., Striano, P., & Arzimanoglou, A. (2017). Expert opinion on the management of Lennox-Gastaut syndrome: Treatment algorithms and practical considerations. Frontiers in Neurology, 8, 505. https://doi.org/10.3389/fneur.2017.00505 Engel, J., Pedley, T. A., Aicardi, J., Dichter, M. A., & Moshé, S. L. (2008). Chapter 96 Lennox-Gastaut Syndrome. In Engel J, Pedley TA (Eds.), Epilepsy: A Comprehensive Textbook (2nd ed., pp. 2331–2341). Lippincott Williams & Wilkins. Laxer, K. D., Trinka, E., & Hirsch, L. J. (Eds.). (2016). Seizures in Long-Term Care. Oxford University Press.