5 Facts you should know about

Angelman syndrome

Angelman syndrome (AS) is characterized by significant developmental delay, severe speech impairment, gait ataxia, and unusual happy demeanor

AS is caused by absence of the maternally inherited copy of the UBE3A gene

More than 80 percent of individuals with AS have seizures by the time they reach two years of age

The characteristic findings of AS are usually diagnosed between 1 and 4 years of age

AS is commonly misdiagnosed with Prader-Willi syndrome, autism and cerebral palsy due to the common characteristics these diseases have

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